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Research Note: Oxyclozanide as Treatment for Small Animal Bacterial Pathogens

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Repurposing existing drugs and using a topical antimicrobial as a first-line treatment option for superficial pyoderma can help promote good antimicrobial stewardship, protect the efficacy of newer systemic antimicrobial classes, and limit use of newer antimicrobial classes. The aim of this study was to provide proof-of-concept for repurposing the drug oxyclozanide, a salicylanilide anthelmintic used primarily in humans and ruminants, as a topical treatment option for superficial pyoderma in small animals. Results showed promising in vitro activity against both methicillin-sensitive and methicillin-resistant Staphylococcus pseudintermedius canine isolates. Pilot data from this study may help guide clinical studies of topical application of oxyclozanide.

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