Although proton-pump inhibitors are more effective acid suppressants as compared with H2-receptor antagonists (eg, famotidine), famotidine remains widely used in veterinary medicine. In humans, dogs, and cows, decreased efficacy of famotidine has been demonstrated with prolonged administration. This study evaluated intragastric pH and serum gastrin concentrations with twice-daily administration (group 1) compared with twice-daily, every-second-day administration (group 2) of famotidine for 14 consecutive days in 16 healthy, adult research colony cats. Results indicate that, by day 13, tolerance developed in group 1 but not in group 2. Future studies on the effects of famotidine on gastric pH in cats with inflammatory, metabolic, and/or neoplastic diseases are indicated.
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