Content continues after advertisement

Research Note: Effect of Prolonged Famotidine Administration in Cats

Sign in to Print/View PDF

Although proton-pump inhibitors are more effective acid suppressants as compared with H2-receptor antagonists (eg, famotidine), famotidine remains widely used in veterinary medicine. In humans, dogs, and cows, decreased efficacy of famotidine has been demonstrated with prolonged administration. This study evaluated intragastric pH and serum gastrin concentrations with twice-daily administration (group 1) compared with twice-daily, every-second-day administration (group 2) of famotidine for 14 consecutive days in 16 healthy, adult research colony cats. Results indicate that, by day 13, tolerance developed in group 1 but not in group 2. Future studies on the effects of famotidine on gastric pH in cats with inflammatory, metabolic, and/or neoplastic diseases are indicated.


For global readers, a calculator to convert laboratory values, dosages, and other measurements to SI units can be found here.

All Clinician's Brief content is reviewed for accuracy at the time of publication. Previously published content may not reflect recent developments in research and practice.

Material from Clinician's Brief may not be reproduced, distributed, or used in whole or in part without prior permission of Educational Concepts, LLC. For questions or inquiries please contact us.


Clinician's Brief:
The Podcast
Listen as host Alyssa Watson, DVM, talks with the authors of your favorite Clinician’s Brief articles. Dig deeper and explore the conversations behind the content here.
Clinician's Brief provides relevant diagnostic and treatment information for small animal practitioners. It has been ranked the #1 most essential publication by small animal veterinarians for 9 years.*

*2007-2017 PERQ and Essential Media Studies

© 2023 Educational Concepts, L.L.C. dba Brief Media ™ All Rights Reserved. Terms & Conditions | DMCA Copyright | Privacy Policy | Acceptable Use Policy