Appropriate management of cardiogenic pulmonary edema relies on quick and accurate diagnosis, which is usually achieved using radiography. Interpretation of images by specialists through teleradiology most often uses the Digital Imaging and Communications in Medicine (DICOM) format. Some studies, however, have concluded that Joint Photographic Experts Group (JPEG) images, found in most smartphone software, are clinically acceptable for diagnostic interpretation. This retrospective study compared the accuracy of these software formats for diagnostic interpretation of cardiogenic pulmonary edema, as well as the diagnostic accuracy between a radiologist versus a cardiologist when interpreting thoracic radiographs. Results showed no significant difference in interpretation of radiographs using either DICOM or JPEG formats and no significant difference in interpretation between a radiologist and a cardiologist.