Feline chronic gingivostomatitis (FCGS) is characterized by intense inflammation of gingival and nongingival mucosa. Many cases are refractory to treatment. Complete extraction of premolars and molars has been the most beneficial treatment to date. In this case report, an 8-year-old spayed female cat with a 1-year history of FCGS was examined. The cat was FeLV- and FIV-negative but was positive for feline calicivirus (FCV) via oral swab. The cat was initially treated by extracting all teeth except the canines. However, the FCGS had not resolved at 2 months. Repeated FeLV and FIV testing was negative, oral swabs for feline herpesvirus were negative, but oral swabs for FCV were still positive. The cat was treated with 1 mega unit/kg SC of feline recombinant interferon-Ω (FeIFN Ω) Q 48 H for 5 treatments. After the last dose, the owner continued treatment with 10,000 IU FeIFN Ω in 2 ml of isotonic saline daily for 2 months and then Q 48 H for an additional month. Oral swabs for FCV were negative at 6 weeks, 14 weeks, and 6 months after starting therapy.

COMMENTARY: FCGS is a frustrating and difficult disease to treat. In this study, FCV was found in association with the disease and seemed to be eradicated after successful elimination of the virus. Currently recombinant interferon-Ω is manufactured by Virbac under the name Virbagen Omega (rFeIFN) and is used to treat FeLV. It is not licensed for use in the United States but will soon be registered in Canada.

Treatment of a case of refractory feline chronic gingivostomatitis with feline recombinant interferon omega. Southerden P, Gorrel C.  J Small Anim Pract 48:104-106, 2007.