Serum Vitamin D Levels in Dogs with Sinonasal Aspergillosis

Source

Snoeck A, Jaffey JA, Billen F, et al. Serum 25-hydroxyvitamin D and 24,25-dihydroxyvitamin D are decreased in dogs with sinonasal aspergillosis. Vet J. 2025;310:106318. doi:10.1016/j.tvjl.2025.106318

Research Note

Sinonasal aspergillosis (SNA), typically caused by Aspergillus fumigatus, is a common cause of chronic nasal disease in dogs. The pathophysiology of SNA is poorly understood, and treatment is challenging. Hypovitaminosis D decreases resistance to A fumigatus in mice and has been associated with many infectious diseases in humans.^1-3

This study evaluated vitamin D metabolite concentrations in healthy dogs (n = 12) and dogs with SNA (n = 22), lymphoplasmacytic rhinitis (n = 9), or nasal neoplasia (n = 10). Serum samples were collected and analyzed for 4 vitamin D metabolites and C-reactive protein. Dogs with SNA were found to have significantly lower serum 25-hydroxyvitamin D₂ and 25-hydroxyvitamin D₃ compared with healthy dogs; no difference was found in dogs with lymphoplasmacytic rhinitis or nasal neoplasia. C-reactive protein concentrations did not differ among groups. Dogs with SNA that were successfully treated had higher serum 25-hydroxyvitamin D₂ and 25-hydroxyvitamin D₃ than before treatment. Although a causal relationship between vitamin D and SNA could not be determined, results suggest vitamin D may play a role in SNA pathophysiology.