This article describes the first documented case of an infiltrative lipoma in a bird. The case involves a 14-year-old, blue-crowned conure of unknown sex that was obtained by the owners as a hatchling from a pet store. The conure lives with 7 other birds but does not have direct contact with them. The bird was presented after a 3-week period of straining to defecate and vocalizing during defecation. Physical examination revealed the following abnormalities: a 2.5-cm diameter subcutaneous soft tissue swelling on the midline of the caudoventral abdomen. The feathers around the cloaca were stained with urates and blood. The cloaca mucosa was hyperemic, edematous, and friable. Blood analysis revealed an increase in creatine kinase and sodium. Polymerase chain reaction assays for avian Polyomavirus and psittacine beak and feather disease antigen were negative. The bird underwent exploratory surgery and a mass extending through the body wall musculature and entering the coelomic cavity was dissected and removed; after removal of the mass, the cloaca returned to its normal position. The histopathologic diagnosis was an infiltrative lipoma. Soon after surgery, the clinical signs resolved and the bird was still doing well 7 months later.