A 12-week-old intact domestic longhaired cat had body tremors progressing to muscle weakness of all four legs, rigid rear extensor muscles, and a distended bladder. By 15 weeks of age the cat had hindlimb paralysis, and by 21 weeks she had developed acute pulmonary distress and died. Globoid cells were seen histopathologically after death. Until now, only two cases of globoid cell leukodystrophy (Krabbe's disease) have been reported in related shorthaired kittens. The disorder is caused by a heritable deficiency of the lysosomal enzyme galactocerebrosidase.

COMMENTARY: Although rare, this condition should be included in the differential diagnosis of kittens with tremors or muscle weakness.

Globoid cell-like leukodystrophy in a domestic longhaired cat. Sigurdson CJ, Basaraba RJ, Mazzaferro EM, Gould DH: Vet Pathol 39:494-496, 2002.