Content continues after advertisement

Apoptosis in Mammary Carcinoma: Not a Survival Indicator

Oncology

|July 2003

Sign in to Print/View PDF

Mammary tumors are the third most common type of neoplasia in female cats. They are usually malignant and progress rapidly. Grading mammary tumors is useful in predicting postsurgical outcome. A recent study in human medicine shows a positive correlation between cell proliferation or tumor grade and apoptosis. This study was conducted to evaluate the role of apoptosis in feline mammary tumors and its relationship with invasiveness and cell proliferation assessed by mitotic index. Thirty-tree tissue samples from cats with malignant primary mammary tumors were evaluated. The neoplasias included several types of carcinoma. Thoracic radiographs and ultrasonograms of the spleen, liver, and kidneys were taken before surgery and every 2 months over a 2-year period. Follow-up was for 2 years or until death due to the tumor.

Three of the cats were graded stage 0 and were alive after 24 months. The 12 cats graded as stage I had a survival time of 21.83 (± 7.83) months. The cats in stage II had a survival time of 13.38 (± 8.99) months. A close correlation was found between the growth fraction expressed by the mitotic index and the infiltrative growth graded as the histologic stage. The apoptotic index in cats showed no correlation with histologic invasiveness or clinical outcome.


Although the apoptotic index was not useful in predicting outcome in cats, this study confirmed the value of histologic grading in predicting postsurgical outcome of cats with mammary tumors.

Rate of apoptosis in feline mammary tumors is not predictive of postsurgical survival. Giuseppe S, Preziosi R, Benazzi C, et al. J VET DIAGN INVEST 15:115-122, 2003.

For global readers, a calculator to convert laboratory values, dosages, and other measurements to SI units can be found here.

All Clinician's Brief content is reviewed for accuracy at the time of publication. Previously published content may not reflect recent developments in research and practice.

Material from Clinician's Brief may not be reproduced, distributed, or used in whole or in part without prior permission of Educational Concepts, LLC. For questions or inquiries please contact us.

Podcasts

Clinician's Brief:
The Podcast
Listen as host Alyssa Watson, DVM, talks with the authors of your favorite Clinician’s Brief articles. Dig deeper and explore the conversations behind the content here.
Clinician's Brief provides relevant diagnostic and treatment information for small animal practitioners. It has been ranked the #1 most essential publication by small animal veterinarians for 9 years.*

*2007-2017 PERQ and Essential Media Studies

© 2023 Educational Concepts, L.L.C. dba Brief Media ™ All Rights Reserved. Terms & Conditions | DMCA Copyright | Privacy Policy | Acceptable Use Policy