Content continues after advertisement

Research Note: Vitamin K-Dependent Coagulopathy: Is Canine Cryopoor Plasma a Viable Treatment?


|November/December 2021

Sign in to Print/View PDF

Anticoagulant rodenticide ingestion is a common toxicosis in veterinary medicine. This in vitro study investigated whether cryopoor plasma (CPP) was as effective as fresh frozen plasma (FFP) in reversing vitamin K-dependent coagulopathy in canine plasma. CPP contains albumin and clotting factors II, VII, IX, and X in amounts similar to FFP. In this experimental model, canine FFP was adsorbed by barium sulfate to mimic vitamin K-dependent coagulopathy. A sequential mixing study in which either FPP or CPP was added to the depleted plasma was then performed. Clotting times, fibrinogen, and coagulation factor activity were measured and compared between the FFP and CPP groups. A dose-dependent decrease was found in prothrombin time and activated partial thromboplastin time when either FFP or CPP was added. Factor VII activity increased significantly more with CPP than FFP. The authors concluded that CPP may be a viable alternative to FPP, pending in vivo studies.


For global readers, a calculator to convert laboratory values, dosages, and other measurements to SI units can be found here.

All Clinician's Brief content is reviewed for accuracy at the time of publication. Previously published content may not reflect recent developments in research and practice.

Material from Clinician's Brief may not be reproduced, distributed, or used in whole or in part without prior permission of Educational Concepts, LLC. For questions or inquiries please contact us.


Clinician's Brief:
The Podcast
Listen as host Alyssa Watson, DVM, talks with the authors of your favorite Clinician’s Brief articles. Dig deeper and explore the conversations behind the content here.
Clinician's Brief provides relevant diagnostic and treatment information for small animal practitioners. It has been ranked the #1 most essential publication by small animal veterinarians for 9 years.*

*2007-2017 PERQ and Essential Media Studies

© 2023 Educational Concepts, L.L.C. dba Brief Media ™ All Rights Reserved. Terms & Conditions | DMCA Copyright | Privacy Policy | Acceptable Use Policy