This prospective, cross-sectional study of 50 pet Persian and exotic cats sought to determine the prevalence of dental anomalies in brachycephalic cats and the potential relationship of brachycephaly and oral disease. Results suggest that these breeds have unique oral and dental features that predisopose them to dental disease; 72% of the cats had malocclusions, 76% had numerical abnormalities (primarily hypodontia), 22% had tooth fractures, 88% had periodontal disease, and 70% had at least one resorptive lesion. Knowledge of predisposition to dental anomalies in feline brachycephalic breeds may help aid in early detection and treatment.