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Research Note: Concurrent Administration & Pharmacokinetics of Extended- Release Levetiracetam

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This study evaluated the pharmacokinetics of extended-release levetiracetam administered as a single agent or concurrently with phenobarbital or zonisamide in epileptic dogs. Results indicated that concurrent administration with phenobarbital led to variability in pharmacokinetics of extended-release levetiracetam, an effect that was not noted with zonisamide. The authors noted that higher doses of extended-release levetiracetam may be needed in some dogs to achieve concentrations considered therapeutic in humans and that drug monitoring may help to determine the optimal dose in individual patients.


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