Content continues after advertisement

Research demonstrates nutritional dissolution of struvite uroliths in as few as 7 days

Hill's Pet Nutrition

June 2014

Sign in to Print/View PDF

Research demonstrates nutritional dissolution of struvite uroliths in as few as 7 days

Nutritional dissolution of naturally occurring struvite uroliths has been an established treatment for more than 30 years. 

But now there is a single nutritional solution that has been clinically tested to dissolve struvite stones in as little as 7 days and also reduce the rate of recurrent episodes of feline idiopathic cystitis (FIC) signs by 89%. 

Recent research published in the Journal of the American Veterinary Medical Association establishes Hill’s® Prescription Diet® c/d® Multicare Feline Bladder Health as the only food clinically tested to dissolve struvite uroliths in as little as 7 days (average 27 days, in vivo study in urolith-forming cats).i  

 “Nutritional dissolution with c/d Multicare has been shown to be rapid, safe and effective,” said Jody Lulich, DVM, PhD, DACVIM, co-Director of the Minnesota Urolith Center (MUC) at the University of Minnesota College of Veterinary Medicine, and lead author of the study.

Despite the proven success associated with nutritional dis¬solution, struvite uroliths remain one of the most common uroliths submit¬ted to laboratories for quantitative analysis, an indication that surgical extraction is often selected for many cats in which non-invasive nutritional dissolution would have resolved the condition with less risk. In 2012, more than 6,000 struvite uroliths were analyzed at MUC, representing  45% of all feline uroliths submitted that year.

In some cases, surgery may be necessary, but the majority of cats with disorders affecting the lower urinary tract can be managed with a multimodal approach consisting of therapeutic nutritional changes and steps to reduce stress, including environmental enrichment. 

c/d Multicare is formulated with controlled levels of magnesium, calcium and phosphorus resulting in reduced building blocks of crystals and uroliths. Clinically proven to maintain urine saturation levels that minimize risks of calcium oxalate crystal growth when fed consistently as an exclusive food, c/d Multicare helps decrease the risk for recurrence of the two most common urolith types in cats.   

“Nutritional dissolution is the compassionate choice for managing struvite uroliths,” Lulich said. “Some veterinarians prefer to remove uroliths surgically due to the perception that surgical management is more effective, but that is not always the case. Medical dissolution of sterile struvite uroliths is more effective than surgery, and is not associated with increased discomfort or urethral obstruction.”

If a feline patient exhibits signs of FIC, a veterinarian should evaluate the cat and perform a urinalysis and diagnostic imaging when appropriate. If uroliths are identified, c/d Multicare can be used as a dissolution food for struvite urolithiasis or for long-term management of struvite or calcium oxalate urolithiasis. If FIC is identified, then c/d Multicare can be used to aid the long-term management of recurrent episodes.

Health care team members may also send uroliths to the University of Minnesota Urolith Center for quantitative analysis. 

The Minnesota Urolith Center has provided quantitative urolith analysis at no cost to veterinary clinics for 30 years. With a database of over 670,000 samples, the Minnesota Urolith Center is able to provide the veterinary community with the latest information on urolith trends and prevention suggestions. With the support of an educational gift from Hill’s Pet Nutrition, the center is now offering on-line submission forms, e-mail notification, and electronic retrieval of results.

After analysis, it is essential to monitor the cat’s progress and emphasize the importance of continuing nutritional management.   

For more information, visit


For global readers, a calculator to convert laboratory values, dosages, and other measurements to SI units can be found here.

All Clinician's Brief content is reviewed for accuracy at the time of publication. Previously published content may not reflect recent developments in research and practice.

Material from Clinician's Brief may not be reproduced, distributed, or used in whole or in part without prior permission of Educational Concepts, LLC. For questions or inquiries please contact us.


Clinician's Brief:
The Podcast

Listen as host Alyssa Watson, DVM, talks with the authors of your favorite Clinician’s Brief articles. Dig deeper and explore the conversations behind the content here.
Clinician's Brief provides relevant diagnostic and treatment information for small animal practitioners. It has been ranked the #1 most essential publication by small animal veterinarians for 9 years.*

*2007-2017 PERQ and Essential Media Studies

© Educational Concepts, L.L.C. dba Brief Media ™ All Rights Reserved. Privacy Policy (Updated 05/08/2018) Terms of Use (Updated 05/08/2018)