Content continues after advertisement

Potential New Screen for UTIs

Clinician's Brief (Capsule)

Clinical Pathology

March 2014

Sign in to Print/View PDF

Microscopic urine sediment examination, common in-clinic screening method for diagnosing urinary tract infections (UTI), is predictive of infection when coupled with urine culture and urinalysis bacterial results. It is only useful, however, when bacteria numbers in unstained urine are >10,000 rods/mL or >100,000 cocci/mL. The Accutest Uriscreen is a catalase-based test for detection of bacteriuria and pyuria. These enzymes are found in most bacteria that infect the urinary tract as well as within somatic cells. It is currently used as a screening test for UTI in humans, but has not been validated for use in dogs and cats.

In this study, 165 urine samples were evaluated for UTI based on bacterial culture, sediment evaluation, or Uriscreen. Twenty-seven samples were positive on bacterial culture; 24 of these tested positive with the Uriscreen. Of the 138 samples that cultured negative, 98 were negative on the Uriscreen (specificity, 71%). The Uriscreen was found to be more sensitive than sediment evaluation for the detection of UTI (89% vs 78%, respectively). False-positive results were common, but UTI was unlikely if results were negative. Limitations include the need for a urine culture and the potential for false-positive results caused by somatic cells in the absence of bacteria or presence of dysplastic cells.


The Uriscreen test may be useful, especially in cases of occult UTI associated with upper urogenital tract infection or increased morbidity. Unfortunately, the test could add to cost without contributing greatly to the diagnostic or prognostic plan, as it has a high number of false-positive and false-negative results. There is no perfect test for urine. The Uriscreen may improve positive predictability of UTI when used with a routine urinalysis while waiting on urine culture results.—Heather Troyer, DVM, DABVP, CVA


Evaluation of a catalase-based urine test for the detection of urinary tract infection in dogs and cats. Kvitko-White HL, Cook AK, Nabity MB, et al. JVIM 10.1111/jvim.12196

This capsule is part of the One Health Initiative.

For global readers, a calculator to convert laboratory values, dosages, and other measurements to SI units can be found here.

All Clinician's Brief content is reviewed for accuracy at the time of publication. Previously published content may not reflect recent developments in research and practice.

Material from Clinician's Brief may not be reproduced, distributed, or used in whole or in part without prior permission of Educational Concepts, LLC. For questions or inquiries please contact us.


Clinician's Brief:
The Podcast
Listen as host Alyssa Watson, DVM, talks with the authors of your favorite Clinician’s Brief articles. Dig deeper and explore the conversations behind the content here.
Clinician's Brief provides relevant diagnostic and treatment information for small animal practitioners. It has been ranked the #1 most essential publication by small animal veterinarians for 9 years.*

*2007-2017 PERQ and Essential Media Studies

© 2022 Educational Concepts, L.L.C. dba Brief Media ™ All Rights Reserved. Terms & Conditions | DMCA Copyright | Privacy Policy | Acceptable Use Policy