When owners observe lameness in cats, clinically important disease is almost always present; other presenting signs (eg, decreased appetite, grooming/behavioral changes) may also be seen. Orthopedic examination should, therefore, be performed consistently. Observance of gait and jumping ability can be facilitated by allowing the cat to move in a room devoid of hiding places, with or without a laser pointer to chase. Asymmetry, head bob, short choppy steps, and plantigrade stance should be investigated. The limbs and spine should be palpated for symmetry; each portion of the limb and joint should be palpated with attention to flexion and extension of each joint. Palpation in lateral recumbency can facilitate the cranial drawer test, the Ortolani sign, and examination of claws and digits. Apparent painful areas should be examined last. Sedation may allow collection of valuable information in some cases. Having a scoring system for the record is helpful.