The effect of NSAIDs or curcumin (found in turmeric) on the gene expression of peripheral WBCs from dogs with osteoarthritis was studied. Blood samples from 12 dogs were taken before and after 20 days of dietary administration of the NSAID (n = 6) or curcumin (n = 6). Genes involved in inflammatory response and in connective tissue development and function dramatically decreased in both groups at day 20. There was also a strong down-regulation of TNF-α and activation of fibrinolysis in the curcumin group. These results suggested that curcumin offers complementary antiinflammatory support for dogs with osteoarthritis.
Transcriptome modification of white blood cells after dietary administration of curcumin and non-steroidal anti-inflammatory drug in osteoarthritic affected dogs. Colitti M, Gaspardo B, Della Pria A, et al. VET IMMUNOL IMMUNOPATHOL 147:136-146, 2012.
For more, see NSAID Therapy in Dogs by Dr. Christopher J. Jones