A 4-year-old bearded dragon was examined for dysecdysis and chronic skin lesions. Initial cytological examination of wound exudate revealed bacilli, cocci, and hyphal elements. Culture revealed Enterococcus spp and Devriesea agamarum. Despite a brief response to ceftiofur, voriconazole, and meloxicam, lesions recurred 3 months later, and culture revealed Clostridium and Chrysosporium spp; the animal was euthanized. Necropsy with histopathological examination revealed severe fatty degeneration and, in some areas, granulomatous hepatitis with intralesional fungal elements. Skin specimens showed severe granulomatous dermatitis with fungal elements.