Histoplasmosis, a deep fungal infection caused by Histoplasma capsulatum, is most common in North, Central, and South America; Africa; India; and Asia. In Europe, the disease has only been reported once: A castrated outdoor cat presented with a one-month history of papules and nodules, some of which were ulcerated and drained a serosanguineous fluid. Cytological examination of exudate was suggestive of a fungal infection, and histologic examination of skin biopsy specimens revealed organisms compatible with H capsulatum var capsulatum. Fungal culture was negative, and diagnosis was confirmed by PCR. There was no evidence of systemic involvement on physical examination, laboratory testing, or imaging. Given that the distribution of the lesions was limited to the skin, treatment consisted of surgical excision of nodules and oral itraconazole at 5 mg/kg q24 for 12 weeks. At 8-month follow up, the cat was healthy with no evidence of recurrence.