Enzyme Cleaners-Not Just for Laundry
The minimum inhibitory concentration (MIC) of a milk-based, enzymatic, antimicrobial product (Zymox Otic, Pet King Brands, Westmont, IL) in solution against 3 gram-negative organisms, 4 gram-positive organisms, and 2 fungi was measured in this study. Growth was inhibited in every organism tested at various test compound dilutions. The agent exhibited an MIC at the greatest dilution, 1:32, against Streptococcus pyogenes, and at a 1:16 dilution against Streptococcus aureus, Escherichia coli, Staphylococcus intermedius, Candida albicans, Pseudomonas aeruginosa, Corynebacterium diphtheriae, and Malassezia pachydermatis. Proteus mirabilis was inhibited at a dilution of 1:8.

COMMENTARY: This enzymatic solution is recommended for treatment of acute or chronic ear infections. The activity is derived from anti-microbial proteins and enzymes that are naturally present in milk and which have the ability to inhibit a broad-spectrum of bacteria, viruses, and fungi. This study was in vitro so the solution remains to be tested in actual cases. Remember that to control ear infections, the underlying cause-such as allergy or parasites-must be addressed.


In vitro antimicrobial activity assessment of Zymox Otic solution against a broad range of microbial organisms. Rajvinder A. J APPL RES VET MED 1:240.