Meningoencephalomyelitis of unknown etiology (MUE) is treated with prednisone, either alone or in combination with other immunosuppressive drugs. Mycophenolate mofetil (MMF) has been used to treat MUE in dogs but has not been assessed in a larger-scale study.
This retrospective case series described the response, adverse events, and outcomes associated with combination MMF–prednisone treatment for MUE. Partial or complete response was achieved in 95% of dogs. Hemorrhagic diarrhea was the most commonly described side effect (20%). Treatment was stopped within 14 days in affected dogs, and those cases were excluded from further statistical analysis. Larger-scale controlled prospective studies are warranted to evaluate the efficacy of MMF as an adjunct treatment for MUE.