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In this episode, host Alyssa Watson, DVM, welcomes Jennifer L. Davis, DVM, PhD, DACVIM (LA), DACVCP, to discuss her recent Clinician’s Brief article, “Pharmacokinetics 101 for Veterinarians.” Dr. Davis’ practical explanations will give you the right understanding about what happens to drugs once they’re given to patients—and what you should do about it. This is like your conceptual intro class about all the stuff you skip over in drug monographs: Cmax, AUC, volume of distribution, etc.
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Key Takeaways
Pharmacokinetics reflect what the body does with a drug and explain why certain drugs do or don’t work in certain patients or situations.
Area under the curve (AUC) and maximum concentration (Cmax) are ways of quantifying how much drug gets into the body, and these can change depending on mode of administration.
Tmax is the time it takes to reach Cmax and correlates with time to effect.
Volume of distribution refers to how far out of the blood a drug will travel with associated factors like lipophilicity, protein-binding, and ionization that impact a drug’s access to privileged sites.
Metabolism, elimination, and clearance describe different aspects of how the drug leaves the body, and these are highly relevant in assessing toxicity risk or determining dosing intervals.
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The Team:
Alyssa Watson, DVM - Host
Alexis Ussery - Producer & Multimedia Specialist