May 2017
Cardiology
Peer Reviewed

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For a comprehensive outline of cardiology history & diagnostics, see Clinical Cardiology History & Diagnostics by Drs. Mandese and Estrada.

A thorough physical examination is valuable for diagnosing heart disease and should include extensive examination of all body systems.

General Appearance

Weight loss is common in patients with advanced cardiac disease. In one study, >50% of dogs with dilated cardiomyopathy experienced cardiac cachexia (ie, loss of lean body mass).1 Low body weight and failure to grow normally can also be signs of congenital cardiac disease in pediatric patients. 

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The Physical Examination
Echocardiography in General Practice: 4 Views to Master

Ocular Examination

Enlarged retinal vessels, retinal hemorrhage, or retinal detachment often indicates systemic hypertension, which can be primary (ie, idiopathic) or secondary to conditions such as renal or cardiac disease, hyperadrenocorticism, diabetes mellitus, pre-eclampsia, and hyperthyroidism. In patients with inconclusive laboratory results, echocardiography can be used to identify underlying heart conditions that cause hypertension (eg, hypertrophic cardiomyopathy in cats, myxomatous mitral valve disease and cardiac overload in dogs). Cardiac changes secondary to hypertension include myxomatous mitral valve disease, left atrial enlargement, or left ventricular hypertrophy.2 

Oral Examination

Pale mucous membranes can indicate shock or anemia, and hyperemic or injected mucous membranes can indicate infection or polycythemia. Cyanosis occurs primarily in patients with cardiac defects that result in right-to-left shunting, such as reverse patent ductus arteriosus, atrial septal defect, and ventricular septal defect. Other health conditions, such as severe hypothermia or severe respiratory disease, can also cause cyanosis. In differential cyanosis, the lower extremities and vulva/prepuce appear cyanotic but the upper extremities and oral mucous membranes are pink and well oxygenated.3 

Several congenital cardiac defects are associated with differential cyanosis, but it is most commonly seen with a reverse patent ductus arteriosus. Periodontal disease should be assessed and noted, as secondary cardiac complications (eg, endocarditis) are possible if severe periodontal disease is not addressed.4 

Tracheal Palpation

Tracheal palpation should be performed on all coughing dogs. Small-breed dogs more prone to myxomatous mitral valve disease are also more prone to a collapsing trachea. In both of these conditions, cough can occur during exercise or excitement5 and may be caused by tracheal disease, even if a murmur is present. Coughing can be heard with tracheitis or tracheobronchitis and can be caused by bacterial or viral infection or environmental allergens. 

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Respiratory Rate/Effort

Respiration should be evaluated when the patient is calm. Clients can be trained to take respiratory rates at home, especially while the patient is sleeping. Several phone apps are available to make it easy for clients to obtain accurate readings. One study suggested that most dogs and cats without cardiac disease or with well controlled heart disease will have a resting respiratory rate of <30 breaths/min at home.6 Increased respiratory effort can indicate upper airway disease (effort occurs during inspiration) or lower airway disease (effort occurs during expiration). 

Lung Sounds

Abnormal lung sounds are most common in patients with primary respiratory disease. Lung sounds also may be abnormal in patients with secondary respiratory conditions such as pulmonary edema and pleural effusion. Auscultation of the lungs is not a sensitive means of detecting pulmonary edema or pleural effusion in dogs and cats, and many patients have pulmonary edema with no auscultatory abnormalities other than increased bronchovesicular sounds.7 Patients with severe pulmonary edema resulting in free fluid in the airways are more likely to have audible crackles; crackles can also be auscultated in patients with pulmonary hypertension, bronchitis, and pneumonia. Muffled lung sounds can indicate pleural effusion. Wheezes are associated with allergic airway disease, bronchitis, and collapsing trachea. 

Heart Rate

Stress and anxiety associated with the veterinary environment can markedly increase a patient’s heart rate. Waiting for a patient’s initial arrival excitement to subside and asking the client to be present during examination can help the clinician obtain a normal heart rate. The client can also be asked to obtain the patient’s resting heart rate at home. If an arrhythmia is present, the type (eg, tachyarrhythmia, bradyarrhythmia) should be noted and the nature characterized. 

Pulse

Pulse pressure can be decreased or increased or have an altered configuration. Decreased pulse pressure may be seen in patients with dilated cardiomyopathy, aortic or pulmonic stenosis, heart failure, hypovolemia, or shock. Increased pulse pressure can occur because of excitement and/or pain or hypertrophic cardiomyopathy.8 Dogs with aortic regurgitation commonly have a bounding pulse. Bounding pulses can also be felt in patients with patent ductus arteriosus, severe bradycardia, hyperthyroidism, fever, or anemia. 

Alterations in pulse conformation also may occur. Dogs with severe subaortic stenosis can have a weak pulse or a pulse pressure that increases more slowly and peaks later during systole (ie, pulsus parvus et tardus). Conversely, dogs with mitral regurgitation commonly have a brisk pulse that rises more rapidly in systole and lasts a shorter time. Other pulse abnormalities include pulsus paradoxus and pulse deficits. Pulsus paradoxus is an increase in pulse pressure on expiration and a decrease on inspiration. This occurs normally but is exaggerated in cardiac tamponade. Pulse deficits can occur with cardiac tachyarrhythmias in which beats occur so rapidly that the ventricle does not have time to fill with an adequate amount of blood before ejection (eg, fast atrial fibrillation, ventricular premature beats).7 Pulse should always be monitored while performing cardiac auscultation to detect pulse deficits. 

Blood Pressure

Obtaining a systolic blood pressure using a Doppler is a relatively simple procedure. To obtain the most accurate reading, blood pressure should be measured in a quiet, calm environment with the client present, if possible. Proper technique, including appropriate cuff width (ie, 40% of the circumference of the limb or tail) is integral to obtaining an accurate measurement. A minimum of 3 measurements should be obtained, and the variability between measurements should be <20%.9

Heart Sounds

The first heart sound (S1) is produced by closing of the mitral and tricuspid valves. S1 is loudest over the mitral valve area and is louder, longer, and lower pitched than the second heart sound (S2). S2 is produced by closing of the pulmonic and aortic valves. S2 is shorter and higher pitched than S1. 

The third heart sound (S3) is not usually heard during auscultation of healthy small animals, and its presence indicates myocardial failure. The sound is generated during the period of rapid filling in early diastole when the ventricles suddenly resist expansion. 

The fourth heart sound (S4) originates from the vibration generated by cardiac structures when the atria contract. It can be a normal finding in giant-breed dogs and large animals or be associated with advanced hypertrophic cardiomyopathy. The presence of an S3 or S4 is referred to as a diastolic gallop. When a diastolic gallop is present, further evaluation is warranted. 

Systolic clicks are found in dogs with chronic valvular disease and originate from vibrations that occur when chordae tendineae and the mitral leaflets suddenly resist further stretching and protrude into the left atrium.10 Muffled heart sounds may indicate the presence of pericardial or pleural effusion.

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Arrhythmias

Sinus arrhythmia is common in dogs, especially in patients who are relaxed and have a lower heart rate. The heart rhythm is faster on inspiration and slower on expiration. When the patient becomes more excited or active, the sinus arrhythmia is often no longer heard. Sinus arrhythmia does not always correspond to respiration and can occur with other causes of increased vagal tone (eg, GI disease).11 Pulses should be palpated in conjunction with auscultation to determine if pulse deficits are present. Sinus arrhythmia was previously thought to be uncommon in cats, but a 2009 study determined that relaxed cats in their home environment can have frequent sinus arrhythmia.12

Common abnormal rhythms include: 

    • Premature beats with pulse deficits: Associated with atrial and ventricular premature complexes. Can occur in bursts or be sustained
    • Irregularly irregular rhythm: Associated with atrial fibrillation. Has been described as “shoes in a dryer”
    • Slow arrhythmia with intermittent pauses: Heard in patients with AV block or sinus arrhythmia
    • Persistent tachycardia or persistent bradycardia: Clients should be informed that an abnormality in heart rate and/or rhythm requires additional testing to determine the cause. 
    • Murmurs: Caused by turbulence disturbing the normal laminar flow of blood, which most often is caused by dysfunctional valves or septal defects. Can also have physiologic causes because of patient size, athletic ability, or underlying noncardiac disease processes (eg, fever, anemia)13
    •  

Related Articles
Heart Murmurs in Cats
Heart Murmurs in Dogs

     
Table 1
Common Pathologic Causes of Murmurs Based on Timing7
Murmur TypePathologic Cause
Systolic murmur

Atrioventricular valve regurgitation

Left-to-right shunt

Increased flow (hyperthyroidism) 

Aortic or pulmonic stenosis

Ventricular septal defect/atrial septal defect (often not audible)

Diastolic murmur

Aortic regurgitation

Pulmonary regurgitation

Mitral stenosis

Endocarditis

Continuous murmurPatent ductus arteriosus 

Characterization of murmurs is based on several criteria: 

  • Timing in the cycle: A systolic murmur occurs between S1 and S2 and is common in small animals. A diastolic murmur occurs between S2 of one beat and S1 of the following beat and is uncommon in small animals. A continuous murmur can be heard throughout the cardiac cycle (Table 1).
  • Location: Location or point of maximal intensity (PMI) refers to the valve area at which the murmur is heard loudest. Recognition of the PMI can help identify the specific cardiac abnormality (Table 2; Figures 1-5). 
  • Intensity
    • Murmurs are graded on a scale of 1 to 6. This scale can be subjective and may vary between observers. 
      • Grade 1/6: Softest murmur audible. May only be heard in a quiet room after listening for several minutes. May not be audible to all observers, and may be transient
      • Grade 2/6: Soft but more easily heard. Often focal over one valve only
      • Grade 3/6: Prominent and easily heard. May radiate to other areas
      • Grade 4/6: Loud and radiates widely. Not accompanied by a palpable thrill
      • Grade 5/6: Loud and accompanied by a palpable thrill
      • Grade 6/6: Loud, accompanied by a palpable thrill, and can be heard with the stethoscope barely touching the thorax
    • Innocent murmurs are soft, systolic, heard best at the mitral or aortic valves, and often low-grade (grade 1). They do not radiate. They are often auscultated in young puppies and kittens and usually disappear by 3 to 4 months of age.
    • Physiologic murmurs are soft and usually of low intensity (grade 1-2). PMI is at the heart base in the area of the outflow tracts (aortic and pulmonic area). These murmurs typically resolve with resolution of the underlying disease. They may also be heard in otherwise healthy animals that are deep chested and/or athletic. They do not indicate any underlying cardiac disorder that can be identified by chest radiography or echocardiography and are common in animals with anemia and occurs as a result of changes in blood viscosity.
  • Character: Most murmurs have characteristic sounds on auscultation:7
    • Harsh or regurgitant: Mimicked by placing the back of the tongue close to the roof of the mouth and blowing out forcefully. Heard in patients with ventricular septal defects and atrioventricular valve insufficiency
    • Blowing: Mimicked by blowing air with moderate force through slightly parted lips. Often heard in patients with aortic or pulmonic insufficiency
    • Machinery: Sounds like the wind blowing through a tunnel. Most often heard in patients with patent ductus arteriosus
    • Systolic clicks: High frequency sounds heard over the left apex that may indicate mitral valve disease
    • Crescendo-decrescendo: An ejection murmur most common in patients with atrial septal defects and aortic or pulmonic stenosis
Table 2
Localization of Murmurs in Common Cardiac Lesions7
ConditionLeft BaseRight BaseLeft ApexRight ApexRight Sternum
Mitral regurgitation   Systolic PMI(+/- Systolic referred) 
Tricuspid regurgitation   Systolic PMI 
Aortic regurgitationDiastolic PMI+/- Diastolic(Diastolic referred)  
Aortic stenosisSystolic PMI+/- Systolic+/- Systolic  
Pulmonic stenosisSystolic PMI    
Ventricular septal defect+/- Systolic (often not heard)   Systolic PMI
Atrial septal defect+/- Systolic (often not heard)    
Tetralogy of FallotSystolic PMI   +/-  Systolic
Patent ductus arteriosusContinuous PMI    

Heart murmurs are present in approximately one-third of apparently healthy adult cats.14-16 The intensity of these murmurs can vary with sympathetic tone and usually increases as heart rate increases. The murmur can disappear entirely when sympathetic stimulation abates and heart rate slows. A murmur may be audible on initial auscultation and may soften or disappear as the patient relaxes during the examination.

Hypertrophic cardiomyopathy and systolic anterior motion of the mitral valve are the most common diagnoses in cats with murmurs caused by heart disease.14-16 Because benign murmurs and murmurs caused by cardiac disease are dynamic and audibly indistinguishable, further evaluation is warranted when a murmur is detected.17

Abdominal Palpation

Ascites and/or liver enlargement may be present in patients with right-sided heart failure. 

Step-by-Step

CARDIAC AUSCULTATION

Cardiac auscultation is best performed in a quiet room with a standing patient. In anxious dogs, panting sounds can be mistaken for murmurs. Manually close the dog’s mouth for a short time during auscultation and give panting breaks as needed. Purring in cats can also be mistaken for a murmur. Distract the cat with a toy or change the position or location of the patient to stop purring. 

Step 1

Place the stethoscope over the left cardiac apex (location of ventricles) and base (location of pulmonary and aortic outflow tracts), right cardiac apex and base, the length of the sternum, and the thoracic inlet. 

Step 2

Auscultate each heart valve at its PMI (Table 3).

Table 3
STETHOSCOPE PLACEMENT FOR CARDIAC EXAMINATION
ValvePoint of Maximal Intensity
MitralLeft 5th intercostal space at costochondral junction
TricuspidBetween right intercostal spaces 3-5 just above costochondral junction
PulmonicBetween left intercostal spaces 2-4 just above sternum
AorticWithin left intercostal space 4-5 just above costrochondral junction

Conclusion

Cardiac abnormalities can be identified during a basic cardiac examination that includes obtaining a complete history and performing a thorough physical examination and simple diagnostics. Creating a list of differential diagnoses based on the information gathered during the cardiac examination can help the clinician make informed decisions about the appropriate next diagnostic or therapeutic step.

PMI = point of maximal intensity
References and author information Show
References
  1. Freeman LM, Rush JE, Kehayias JJ, et al. Nutrition alterations and the effect of fish oil supplementation in dogs with heart failure. J Vet Intern Med. 1998;12(6):440-448.
  2. Davies C, Shell L. Systemic hypertension. In: Davies C, Shell L, eds. Common Small Animal Medical Diagnoses: An Algorithmic Approach. Saunders; 2002. Accessed on Veterinary Information Network, April 18, 2017.
  3. Kittleson MD. Diagnosis. In: Kittleson MD, Kienle RD, eds. Small Animal Cardiovascular Medicine. Maryland Heights, MO: Mosby Elsevier; 2005. Accessed on Veterinary Information Network, April 18, 2017.
  4. Glickman LT, Glickman NW, Moore GE, Goldstein GS, Lewis HB. Evaluation of the risk of endocarditis and other cardiovascular events on the basis of the severity of periodontal disease in dogs. J Am Vet Med Assoc. 2009;234(4):486-494.
  5. Tappin SW. Canine tracheal collapse. J Small Anim Pract. 2016;57(1):9-17.
  6. Porciello F, Rishniw M, Ljungvall I, Ferasin L, Haggstrom J, Ohad DG. Sleeping and resting respiratory rates in dogs and cats with medically-controlled left-sided congestive heart failure. Vet J. 2016;207:164-168. 
  7. Kittleson MD, Kienle RD. Physical exam. In: Kittleson MD, Kienle RD, eds. Small Animal Cardiovascular Medicine. Maryland Heights, MO: Mosby Elsevier; 2005. Accessed on Veterinary Information Network, April 18, 2017.
  8. Ware WA. Clinical manifestations of cardiac disease. In: Nelson RW, Couto CG, eds. Small Animal Internal Medicine. 5th ed. St. Louis, MO: Elsevier; 2014:6.
  9. Ferasin L. How to measure blood pressure. Presented at: British Small Animal Veterinary Congress; 2011. Accessed on Veterinary Information Network, April 18, 2017.
  10. Kvart C, Häggström. Heart sounds and murmurs in dogs and cats. In: Kvart C, Häggström J. Cardiac Auscultation & Phonocardiography in Dogs, Horses and Cats; 2002. Accessed on Veterinary Information Network, April 18, 2017.  
  11. Kittleson MD. Specific arrhythmias. In: Kittleson MD, Kienle RD, eds. Small Animal Cardiovascular Medicine. Maryland Heights, MO: Mosby Elsevier; 2005. Accessed on Veterinary Information Network, April 18, 2017.
  12. Hanås S, Tidholm A, Egenvall A, Holst BS. Twenty-four hour Holter monitoring of unsedated healthy cats in the home environment. J Vet Cardiol. 2009;11(1):17-22. 
  13. Kvart C, Häggström J. Heart sounds and murmurs in dogs and cats: physiological flow murmurs. In: Kvart C, Häggström J. Cardiac Auscultation & Phonocardiography in Dogs, Horses and Cats; 2002. Accessed on Veterinary Information Network, April 18, 2017. 
  14. Paige CF, Abbott JA, Elvinger F, Pyle RL. Prevalence of cardiomyopathy in apparently healthy cats. J Am Vet Med Assoc. 2009;234(11):1398-1403. 
  15. Wagner T, Fuentes VL, Payne JR, McDermott N, Brodbelt D. Comparison of auscultatory and echocardiographic findings in healthy adult cats. J Vet Cardiol. 2010;12(3):171-182. 
  16. Nakumura RK, Rishniw M, King MK, Sammarco CD. Prevalence of echocardiographic evidence of cardiac disease in apparently healthy cats with murmurs. J Feline Med Surg. 2011;13(4):266-271. 
  17. Côté E, Manning AM, Emerson D, Laste NJ, Malakoff RL, Harpster NK. Assessment of the prevalence of heart murmurs in overtly healthy cats. J Am Vet Med Assoc. 2004;225(3):384-388. 
Authors

Wendy W. Mandese

DVM University of Florida

Wendy W. Mandese, DVM, is a clinical assistant professor and course coordinator at University of Florida, where she also earned her DVM. Her clinical interests are in dentistry, stress-free handling, and palliative care. Dr. Mandese has more than 10 years of experience in small animal general practice and has been in her current position for 5 years. 

Amara Estrada

DVM, DACVIM (Cardiology) University of Florida

Amara Estrada, DVM, DACVIM (Cardiology), is associate professor of the cardiology department, associate chair for the department of small animal clinical sciences, and director of the Teaching Academy at University of Florida. Dr. Estrada’s research interests include electrophysiology, pacing therapy, complex arrhythmias, cardiac interventional therapy, and cardiac regenerative medicine. Dr. Estrada graduated from University of Florida and completed a cardiology residency at Cornell University.

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