Restraining the patient is probably the biggest challenge of venipuncture in ferrets. Restraint is usually not a problem in very sick ferrets, but most ferrets that need a presurgical assessment are still active and alert. There are two means of stabilization: good assistants and anesthetics. The best way to hold a ferret depends on the site of venipuncture.
In lateral recumbency (Figure 1), which is typically used for blood collection from the saphenous vein, ferrets can be held by the scruff and stretched by the assistant.