A study was conducted to determine the survival time of cats presenting with systolic hypertension and whether the degree of blood pressure control over time influenced their survival. Cats were excluded if they were currently receiving antihypertensive medication. Association of age, renal function, proteinuria, systolic blood pressure over time (SBPOT), and the presence of hyperthyroidism on survival was investigated. Urine protein-to-creatinine ratio (UP:C) was measured at time of diagnosis and again after initiating treatment. All cases were treated with an initial dose of amlodipine besylate (0.625 mg/cat once daily), which is the current treatment of choice. Cats were reexamined after 7 to 21 days to evaluate efficacy. In 50% of cats, it was necessary to increase the dose to 1.25 mg/cat either during stabilization or the follow-up period. The dose was increased if systolic blood pressure measurements remained higher than 160 mm HG upon reexamination. Other medications were prescribed on an individual basis in accordance with underlying disease conditions. Survival times were recorded starting on the day antihypertensive medication was implemented through death/euthanasia or the study end point. Data gathered demonstrated that proteinuria was the variable most significantly associated with survival. A significant decline in the UP:C was found when hypertensive cats were treated with amlodipine besylate. This change was most marked in cats defined as proteinuric at diagnosis of hypertension. Study funded in part by Waltham Centre for Pet Nutrition

COMMENTARY: A good clinically applicable paper, but the reader can get the important information from the abstract or the above Capsule.

Effect of control of systolic blood pressure on survival in cats with systemic hypertension. Jepson RE, Elliott J, Brodbelt D, Syme HM. J Vet Intern Med 21:402-409, 2007.