Local/regional anesthesia should be considered as part of a multimodal protocol for pain relief after every surgery and traumatic injury.1-5,18,19 Local anesthetic drugs block pain transmission to the CNS, making them highly effective analgesics.18 Most of these drugs are inexpensive and most blocks are relatively easy to administer.1-5,18,19 In most patients, local anesthetic blockade provides profound pain relief (block-, drug-, and procedure-specific) both during the procedure and into recovery, beyond the drug’s expected duration of action.20-22 This is an important mechanism because it can be complicated to treat pain during recovery in some patients due to limited options and potential drug contraindications with specific diseases (eg, NSAIDs in most patients with renal disease). Local/regional blockade also decreases surgery-related chronic pain development in humans,23 and due to the commonality of the mammalian pain pathway, this effect is predicted to occur in cats. Lidocaine, bupivacaine, and ropivacaine are commonly used local anesthetics in cats. Liposome-encapsulated bupivacaine provides analgesia for 72 hours, is FDA-approved for use in cats for peripheral nerve blocks,24 and is commonly used for other blocks.18,19 Local and regional techniques for cats include oral blocks,1-5,18-20,25 coccygeal epidurals,1-5,18,19,26,27 lumbosacral epidurals,1-5,18,19,28 testicular blocks,1-5,18,19,29,30 and uterine/ovarian blocks or peritoneal lavage (Figure 2).1-5,18,19,21,22,31-33