Markers of Severity in Dogs With Immune-Mediated Thrombocytopenia

ArticleLast Updated March 20241 min read
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Brooks MB, Goggs R, Frye AH, et al. A prospective cohort study to identify clinical diagnostic and prognostic markers of primary immune thrombocytopenia in dogs. J Vet Intern Med. 2024;38(2):1022-1034. doi:10.1111/jvim.16985

Research Note

Primary immune-mediated thrombocytopenia (ITP) is a diagnosis of exclusion in dogs, as there are no pathognomonic signs or definitive diagnostic tests for this disease. The clinical course of disease varies, and platelet counts at presentation are poorly predictive of bleeding severity and treatment responsiveness.

This prospective study compared clinicopathologic features of dogs with primary ITP (n = 58) and dogs with secondary ITP (n = 40) to identify differentiating diagnostic criteria and laboratory biomarkers related to bleeding risk, need for transfusion, and survival. Dogs with primary ITP had lower platelet counts, decreased expression of platelet membrane proteins, and lower D dimer concentrations, but no single diagnostic test clearly distinguished primary ITP from secondary ITP. Hematocrit measured at the time of hospital admission was the only variable associated with need for transfusion in dogs with primary ITP, and low hematocrit and high BUN at admission were associated with nonsurvival to discharge. Platelet count at admission did not correlate with clinical bleeding score, need for transfusion, or survival.