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Buccally administered, compounded buprenorphine is a frequently used pain medication in cats. The long-term stability of compounded buprenorphine solutions is unknown. 

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In this study, the authors used high-performance liquid chromatography to determine the stability of a 3 mg/mL-compounded buprenorphine product. The formulation remained stable under refrigeration and at room temperature for 90 days. However, some of the room-temperature samples developed a white sediment, and pH decreased over time, indicating possible degradation. 

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The authors concluded that the 3 mg/mL-compounded buprenorphine product is stable for 90 days when refrigerated and stored in amber glass bottles.

References Show


Kirk LM, Brown SD. Beyond-use date determination of buprenorphine buccal solution using a stability-indicating high-performance liquid chromatographic assay. J Feline Med Surg. 2015;17(12):1034-1040.

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