Content continues after advertisement

Research Note: Point-of-Care Test for Mushroom-Related Amatoxicosis in Dogs

Sign in to Print/View PDF

Amatoxins are the causative agent of mushroom hepatotoxicosis and can affect multiple organ systems but primarily target the liver. Initial signs (eg, vomiting, lethargy, fever, hypoglycemia) are not pathognomonic and can be mistaken for other conditions (eg, anaphylaxis, sepsis, other causes of acute hepatic failure), especially when ingestion is not suspected or witnessed. Presumptive diagnosis is generally based on patient history, clinical signs, and changes in the serum chemistry profile; however, an inexpensive point-of-care lateral flow immunoassay for amanitin detection in canine urine is commercially available. 

This case study was the first to report diagnosis of amatoxicosis via point-of-care lateral flow immunoassay in a dog prior to treatment. The patient made a full recovery and was discharged 4 days after hospitalization. Early diagnosis can help guide treatment decisions; additional studies are needed to determine whether survival rates improve with early detection.

Source & References

For global readers, a calculator to convert laboratory values, dosages, and other measurements to SI units can be found here.

All Clinician's Brief content is reviewed for accuracy at the time of publication. Previously published content may not reflect recent developments in research and practice.

Material from Clinician's Brief may not be reproduced, distributed, or used in whole or in part without prior permission of Educational Concepts, LLC. For questions or inquiries please contact us.


Clinician's Brief:
The Podcast
Listen as host Alyssa Watson, DVM, talks with the authors of your favorite Clinician’s Brief articles. Dig deeper and explore the conversations behind the content here.
Clinician's Brief provides relevant diagnostic and treatment information for small animal practitioners. It has been ranked the #1 most essential publication by small animal veterinarians for 9 years.*

*2007-2017 PERQ and Essential Media Studies

© 2023 Educational Concepts, L.L.C. dba Brief Media ™ All Rights Reserved. Terms & Conditions | DMCA Copyright | Privacy Policy | Acceptable Use Policy