Content continues after advertisement

Research Note: Canine Cytochrome B Blood Mutations

Infectious Disease

|November 2019

Sign in to Print/View PDF

Mutations in Babesia gibsoni mitochondrial cytochrome b genes—specifically at the M128 position—are associated with resistance to atovaquone, which can lead to treatment failure. This study sought to determine M128 mutation prevalence in B gibsoni in blood from dogs in North America. The study also evaluated how many of these patients had wild-type cytochrome b in initial blood samples and M128 mutations in follow-up samples. Prevalence of the M128 mutation in the 173 dogs tested was 3.5%; incidence of new cytochrome b mutations in the 43 dogs with follow-up testing was 12.1%. American Staffordshire/American pit bull terriers comprised 74% of dogs infected with B gibsoni in this study. The authors concluded that the cytochrome b mutation is not common enough to warrant pretreatment mutation screening prior to therapy. 

Source

For global readers, a calculator to convert laboratory values, dosages, and other measurements to SI units can be found here.

Material from Clinician's Brief may not be reproduced, distributed, or used in whole or in part without prior permission of Educational Concepts, LLC. For questions or inquiries please contact us.

Podcasts

Clinician's Brief:
The Podcast

Listen as host Beckie Mossor, RVT, talks with the authors of your favorite Clinician’s Brief articles. Dig deeper and explore the conversations behind the content here.
Clinician's Brief provides relevant diagnostic and treatment information for small animal practitioners. It has been ranked the #1 most essential publication by small animal veterinarians for 9 years.*

*2007-2017 PERQ and Essential Media Studies

© 2018 Educational Concepts, L.L.C. dba Brief Media ™ All Rights Reserved. Privacy Policy (Updated 05/08/2018) Terms of Use (Updated 05/08/2018)