Each year in the U.S., several thousand cases of rabies are diagnosed in wildlife, particularly among reservoir species (eg, raccoons, skunks, foxes, bats), and several hundred cases are diagnosed in domestic animals. Cats account for nearly 50% of domestic animal cases.1 In countries where canine rabies has been controlled but wildlife rabies remains, cats are often a greater source of rabies exposure to humans than are dogs2 and are considered highly susceptible to infection and highly capable of transmission.3,4 There is some debate as to whether cats are more susceptible to rabies than dogs, and results appear to be dependent on the challenge virus used in experimental studies.2 Cats also appear more susceptible to wildlife isolates but less susceptible to canine isolates.2 Specific feline rabies strains have not been documented, and intraspecific transmission among cats appears limited.3