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Quiz: Mast Cell Tumors

Jennifer L. Willcox, DVM, DACVIM (Oncology), University of California, Davis

Oncology

|April 2017|Peer Reviewed|Web-Exclusive

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6  Questions
Multiple Choice Questions
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Quiz: Mast Cell Tumors

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Clinician's Brief

Renae, a 4-year-old spayed pug, is presented for an erythematous nodule located along the trunk. On presentation, the mass measures ~1 cm in diameter. However, according to the owners, the mass had become noticeably larger, then decreased in size. An aspirate is obtained, and one of the cytology slides is stained in-house with Diff-Quik.

Round cells with a round nucleus and more cytoplasm than a lymphocyte or lymphoblast are noted on in-house microscopy. The cytoplasm is free of obvious granules. Because the diagnosis is not clear-cut based on in-house testing, the additional samples are submitted to a clinical pathologist for cytology; the findings indicate a mast cell tumor (MCT). 

Why was the diagnosis unclear based on in-house Diff-Quik staining?

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Quiz: Mast Cell Tumors
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Clinician's Brief

Bryce, a 7-year-old castrated Boston terrier, is presented for a soft, fluctuant mass measuring 3 cm, located caudorsally on the flank. According to the owners, the mass has been present for several months and has not changed considerably in size. After noting the mass, a groomer had encouraged the owners to present their dog for evaluation.  

What would be the most appropriate next step for this dog?

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Quiz: Mast Cell Tumors
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In the same Boston terrier as presented in question 2, FNA of the mass reveals an abundance of mast cells. The clinical pathologist confirms the diagnosis of MCT.  

Which of the following options are the most appropriate recommendations for this dog, depending on the owners’ wishes? Choose all answers that could apply.

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Quiz: Mast Cell Tumors
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Clinician's Brief

Lexi, an 8-year-old female Labrador retriever, has been diagnosed with an MCT of the left ear pinna. Incisional biopsy findings indicate a grade II mass on the Patnaik scheme and high-grade mass on the Kiupel scheme. The owners are interested in a full workup as well as appropriate staging diagnostics.  

Considering the histopathologic findings, which staging approach would be recommended for this dog?

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Quiz: Mast Cell Tumors
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In the same Labrador retriever as presented in question 4, the owners opt to proceed with staging diagnostics. MCT metastasis is found in the left submandibular lymph node.  

How should the clinician proceed with treatment for this dog?

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Quiz: Mast Cell Tumors
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Clinician's Brief

Persimmons, a 5-year-old spayed boxer, is presented for an annual wellness check after the family recently moved to a new location. Because the patient records have not been transferred yet, the owners advise that Persimmons has a history of a grade 1 Patnaik MCT, which was completely excised the previous year. They would like additional information about MCTs and how recurrence may pertain to their dog.    

Which of the following statements would be most appropriate to share with the owners?

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Quiz: Mast Cell Tumors
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Quiz: Mast Cell Tumors

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