Cryptococcal infections are seen worldwide in various species and, in the United States, are most common in California and the Pacific Northwest.1 Basidiospores are usually found in soil or avian fecal material; infection often occurs through inhalation but can occur via direct contact of basidiospores in open wounds.1-3 Incubation can range from a few months to years.2
Although assays to determine species were not performed in this patient, most cats in California that have cryptococcosis are infected by Cryptococcus gattii VGIII, with relatively fewer infections being due to C gattii VGII.1 C neoformans var grubii is the most common cause of cryptococcosis in dogs and humans; in the United States, cats are rarely infected with this species.1
In cats, cryptococcosis is generally chronic and often presents as mucosal lesions in the nasal cavity, regardless of the primary site of entry/infection of the basidiospores.1-3 The glistening, serosanguinous gelatinous nature of the mass observed in this patient is a characteristic feature of cryptococcosis and a reflection of the presence of the polysaccharide capsule.1,2 Meningoencephalitis, cerebral granulomas, chorioretinitis, optic neuritis, uveitis, and other lesions may also be observed.2,3
Pathogenesis of disease and success of treatment are dependent on the type and extent of infection, host immunity, and strain of Cryptococcus spp involved.1-3 Fungal culture is recommended, as a long course of therapy is required to resolve infection, and antifungal resistance is common.1-3 Antifungals commonly selected for feline therapy include fluconazole (10 mg/kg PO every 12 hours) and itraconazole (5-10 mg/kg PO every 24 hours). Fluconazole is the initial antifungal agent of choice due to its good tissue penetration in the brain, eyes, and urinary tract and its relatively low cost. If the patient fails to respond to fluconazole therapy, as is often seen with C gattii infections, itraconazole may help achieve remission; however, multimodal therapy, including amphotericin B and 5-flucytosine, may be required in severe disseminated cases. Serial laboratory monitoring of liver enzymes is recommended, as liver toxicity is possible with azole therapy (see Treatment at a Glance).1-3
Once cryptococcosis is diagnosed, a discussion should be held with the owner regarding the cost of long-term medication and laboratory monitoring, the importance of owner and patient compliance for long-term oral therapy, and the potential for disease recurrence, particularly if compliance is poor. A committed owner and a compliant patient are essential for a successful outcome.
Treatment success can be gauged by reduction in both clinical signs and serum antigen titers (at least one dilution per month of treatment); treatment should be continued until the antigen titer is 0.1-3 Continued antigen titer monitoring after resolution of disease at 3- to 6-month intervals is recommended, as early detection of relapse can lead to shorter duration of repeat treatment (see Take-Home Messages).2