Content continues after advertisement

Predicting Infection in Acute Traumatic Wounds

Jonathan Miller, DVM, MS, DACVS (Small Animal), Oradell Animal Hospital, Paramus, New Jersey

Surgery, Soft Tissue

|January/February 2021|Web-Exclusive

Sign in to Print/View PDF

In the Literature

Hamil LE, Smeak DD, Johnson VA, Dow SW. Pretreatment aerobic bacterial swab cultures to predict infection in acute open traumatic wounds: A prospective clinical study of 64 dogs. Vet Surg. 2020;49(5):914-922.


Infection development in wounds is common in veterinary patients. Predicting time of infection occurrence can assist in judicious antibiotic use. This study examined bacterial culture results in dogs with wounds caused by bites or other acute cutaneous trauma. Cultures were taken before and after wound lavage with lactated Ringer’s solution.1

The primary objective of this study was to assess the type and quantity of bacteria present in the wound before and after lavage. The secondary objective was to evaluate whether culture results were useful for predicting ultimate wound infection. Size, type, and treatment of wounds by closure were examined in 64 dogs.

The rate of positive culture results significantly decreased from 76.6% before lavage to 56.3% after lavage, with an 86% reduction in the number of bacteria after irrigation. The species of bacteria grown in cultures were the same in 70.3% and different in 29.7% of wounds after lavage. Typical bacteria were Staphylococcus spp, Streptococcus spp, and Pasteurella spp. Although all dogs received a β-lactam antibiotic, 21.9% of wounds developed at least 1 sign of clinical infection during the 30-day follow-up. Postinfection cultures predominantly yielded Staphylococcus spp, Escherichia coli, and Pseudomonas spp, of which 69.2% were resistant to the prescribed prophylactic β-lactam antibiotic.

No relationship was found between development of clinical infection and prelavage culture, postlavage culture, number of bacteria cultured, or the wound size, type, or treatment. Although the reduction in bacteria after wound lavage was encouraging, the lack of reliable predictable factors for developing wound infection is a good reminder of the unpredictable nature of these cases.


Key pearls to put into practice:


Wound lavage with lactated Ringer’s solution is effective for reducing bacterial load.


Cultures collected either before or after lavage do not appear to be helpful in predicting whether a wound will become infected or with which bacteria.



Resistance to prophylactic antibiotics is common in infected wounds.



Wound size, cause, and treatment after lavage do not seem to be useful in predicting infection.


For global readers, a calculator to convert laboratory values, dosages, and other measurements to SI units can be found here.

All Clinician's Brief content is reviewed for accuracy at the time of publication. Previously published content may not reflect recent developments in research and practice.

Material from Clinician's Brief may not be reproduced, distributed, or used in whole or in part without prior permission of Educational Concepts, LLC. For questions or inquiries please contact us.


Clinician's Brief:
The Podcast

Listen as host Alyssa Watson, DVM, talks with the authors of your favorite Clinician’s Brief articles. Dig deeper and explore the conversations behind the content here.
Clinician's Brief provides relevant diagnostic and treatment information for small animal practitioners. It has been ranked the #1 most essential publication by small animal veterinarians for 9 years.*

*2007-2017 PERQ and Essential Media Studies

© Educational Concepts, L.L.C. dba Brief Media ™ All Rights Reserved. Privacy Policy (Updated 05/08/2018) Terms of Use (Updated 05/08/2018)