With eye enucleation, it is critical to control postoperative pain in patients to prevent postoperative complications from face rubbing or self-mutilation. This study compared lidocaine–bupivacaine retrobulbar injections given before enucleation vs lidocaine–bupivacaine infused gelatin hemostatic sponges in the orbit after enucleation for management of postoperative pain. Premedication consisted of hydromorphone, midazolam, and glycopyrrolate. Postextubation pain scores, recorded intermittently for the first 24 hours, were compared with preoperative pain scores. Significant differences were noted with respect to comfort level, response to touch, heart rate, and pain score in individual dogs over time; however, there was no significant difference between groups. One of 8 dogs in the absorbable gelatin hemostatic sponge group required rescue analgesia and none was required in the injection group (n = 11). There were no postoperative complications.