October 2017
Orthopedics
Peer Reviewed

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Video Gait abnormality

History

Jax, a 10-month-old intact male English bulldog, was presented for acute onset of a pelvic limb gait abnormality. Jax was adopted at 6 months of age with no prior medical history reported. Three weeks after adoption, he was presented to the neurology service for a 5-day history of scuffing and dragging both pelvic limb paws when walking (see Gait Abnormality Video). There was no history of trauma or discomfort since adoption. The primary veterinarian performed a routine serum chemistry profile and CBC prior to referral; all results were within normal limits. 

Physical & Neurologic Examination

On examination, Jax was bright, alert, and responsive. Results of cranial nerve examination were normal. Moderate general proprioceptive ataxia and paresis were present in both pelvic limbs. Evaluation of postural reactions revealed delayed proprioceptive positioning in both pelvic limbs; in addition, all segmental reflexes were intact. No hyperpathia was noted on palpation of the vertebral column. Temperature was 102.4°F (39.1°C). The physical examination was otherwise normal.

Based on the neurologic examination, an anatomic diagnosis of T3-L3 myelopathy was made. Differential diagnoses included trauma, infection, inflammation, neoplasia, and a congenital vertebral malformation. A degenerative process (eg, storage disease) was also considered. 

Diagnostics

Imaging of the thoracolumbar vertebral column was performed. Survey radiographs of the vertebral column were obtained because of the possibility of trauma, infection, neoplasia, or a congenital vertebral malformation. For general practitioners, it should be noted that survey radiographs are usually not indicated when intervertebral disk disease is suspected. Although radiographs may show mineralized disks, they are not reliable because they are unable to definitively diagnose which disk is causing the problem and are unable to show the extent of any spinal cord compression. If intervertebral disk disease is the primary consideration, a practitioner should attempt to conserve finances for advanced, confirmatory imaging such as MRI or, in some instances, CT. 

Figure 1 Lateral radiograph of the patient’s vertebral column. Narrowing of the L4-L5 space, reduction of the L4-L5 foramen, and an irregular lucent cleft at the level of the caudal endplate of L4 can be seen (arrow).

A lateral radiograph of Jax’s vertebral column revealed narrowing of the L4-L5 intervertebral disk space, reduction of the L4-L5 intervertebral foramen, and an irregular lucent cleft at the level of the caudal endplate of L4 (Figure 1). These findings were most consistent with physitis (see Discussion) and an associated end plate fracture.

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CT was performed to evaluate bony compartment involvement. The 3 compartments of the vertebral column include dorsal, middle, and ventral compartments. The dorsal compartment is composed of the spinous process, the vertebral arch, the articular process, and the associated ligaments. The middle compartment includes everything ventral to the articular process, including the ventral floor of the vertebral canal and the dorsal portion of the intervertebral disk. The ventral compartment includes the remaining portion of the intervertebral disk and the vertebral body.1 Two compartments were found to be involved: the dorsal vertebral body (ie, middle compartment) and the remaining vertebral body (ie, ventral compartment). 

An MRI was performed and revealed indistinct periosteum with irregular physeal bone and no obvious sign of trauma at the level of L5 (Figure 2). The caudal endplate of L4 and the associated epidural space became strongly enhanced after administration of gadolinium contrast.

Figure 2 Sagittal T1+ contrast MRI revealing indistinct periosteum with irregular physeal bone at the level of L5, with strong enhancement of the L4 caudal endplate and associated epidural space (arrow)

Urinalysis, urine culture and susceptibility, and Brucella canis titer results were within normal limits.

Potential causes for Jax’s physitis and fracture included a traumatic fracture that occurred before adoption and progressed to secondary physitis or a bony reaction secondary to a fracture. However, the most likely cause in this case—based on signalment, author experience, and a similar prior case report2—is active physitis that occurred secondary to infection elsewhere in the body with a subsequent pathologic fracture. 

Treatment

Cephalexin was prescribed at 22 mg/kg q12h for 8 months to treat physitis. An antibiotic regimen lasting 6 to 8 months is generally recommended in cases of vertebral infections because of the possible nature of these infections (see Discussion). 

Typically, if 2 out of 3 compartments are involved in a vertebral column fracture, as in this case, surgical stabilization is recommended. However, the high suspicion of infection made this dog a poor candidate. Strict rest was emphasized to aid fracture healing.1 

Discussion

Physitis refers to inflammation and lysis of the caudal physeal zone of one or more vertebrae.3 This does not include inflammation of the intervertebral disk, which would be referred to as diskospondylitis.3 Diskospondylitis also affects both endplates.3 In cases of physitis and most other vertebral infections, the primary cause or infectious agent is usually not identified.2 It has been hypothesized that physitis arises from hematogenous spread of an infection elsewhere in the body.2 Common sources of a primary infection include the urogenital tract, skin, heart, and oral cavity.2 Infections associated with physitis are most commonly thought to result from the urogenital system when the lumbar vertebrae are involved.2 

Knowledge of the vascular system of the vertebrae and vertebral column is necessary to understand how primary infection elsewhere in the body may result in physitis.

Vascular System

Within the vertebral bodies, venous blood drains through the basivertebral vein. This venous structure (usually paired) occurs in the midbody of the vertebra in an osseous canal. Blood drains dorsally to enter the ventral internal vertebral venous plexus. The ventral internal vertebral venous plexus, also a paired structure, courses from the cranial cavity caudally throughout the vertebral canal. Venous blood from the ventral internal vertebral plexus drains into the intervertebral veins, which course along with spinal nerves out of the vertebral column. In the 5th through 7th lumbar vertebrae, the intervertebral veins continue as paired lumbar veins. At each vertebra, L5 through L7, the paired lumbar veins anastomose with each other and enter the dorsal aspect of the caudal vena cava, which lies immediately ventral to the ventral surface of the lumbar region of the vertebral column. This entire venous system is a collection of valveless vessels. Blood may flow in either direction based on the pressure in the system. The caudal abdominal organs drain into the common iliac vein, which becomes the caudal vena cava.4 Consequently, there is a close relationship with venous drainage of the lumbar vertebrae and caudal abdominal organs (eg, the urogenital tract).2,4,5

With increases in abdominal pressure, there can be a reversal of venous blood flow whereby blood from the caudal vena cava flows retrograde into the basivertebral veins. This retrograde venous flow can transport bacteria and other potentially infectious organisms into the vertebral bodies.2 

For a helpful diagram of the vascular system, see Suggested Reading.

Because of the location of the lesion in this case, it was hypothesized that the patient may have had an occult urogenital infection (eg, prostatis) that reached the lumbar vertebrae due to retrograde blood flow through the unique vascular system as previously described.

This hypothesis is based on various research in the human literature showing evidence of prostatic metastasis to the lumbar vertebrae through similar mechanisms6,7 as well as on an author’s previous case in which an occult pyelonephritis was identified following postmortem examination. 

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Research on causative organisms for vertebral infections such as physitis is limited. In diskospondylitis, the most common organism isolated is Staphylococcus spp.2 A primary causative organism has not been isolated for physitis. However, Escherichia coli, Serratia spp, Streptococcus spp, and Staphylococcus spp have been identified in patients with uncomplicated physitis.2 Urine culture and serology for Brucella canis are strongly recommended in all patients. Although there is no clear evidence linking brucellosis to vertebral infections, its zoonotic potential and localization in the urogenital tract make it an imperative rule-out. Although expensive and often negative, blood cultures should also be considered. 

Typically, an antibiotic with efficacy against gram-positive organisms (specifically Staphylococcus spp), such as amoxicillin–clavulanic acid or cephalexin, is recommended. If extensive neurologic deficits are involved, combination therapy with enrofloxacin is recommended to increase the antimicrobial spectrum. Antibiotics should be continued for at least 6 to 8 months or several months past resolution of clinical signs. Pain can be treated with gabapentin or tramadol. If the patient does not respond to pain medication alone, an NSAID (eg, carprofen) may be considered.

In this case, surgical debridement and/or stabilization were not pursued because of the increased risk for implant failure. If a patient does not respond to medical management, surgery may be indicated to debride the region and obtain samples for culture. In these cases, the benefits of surgical intervention are thought to outweigh the risks. 

Outcome

Jax remained on an 8-month course of cephalexin and strict rest. His neurologic signs resolved, antibiotics were discontinued, and his clinical signs never recurred.

References and author information Show
References
  1. Kirby BM. Spinal fracture/luxation. Vet Clin North Am Small Anim Pract. 1995;25(5):1149-1174.
  2. Tepper LC, Glass EN, Kent M. A challenging case: progressive, generalized pain in a young English Bulldog. Vet Med. 2007;102:238-246.
  3. Thomas WB. Diskospondylitis and other vertebral infections. Vet Clin North Am Small Anim Pract. 2000;30(1):169-182.
  4. Evans HE, de Lahunta A. Miller’s Anatomy of the Dog. 4th ed. St. Louis, Mo: Elsevier Saunders; 2013. 
  5. de Lahunta A, Glass EN, Kent M. Veterinary Neuroanatomy and Clinical Neurology. 4th ed. St. Louis, MO: Elsevier Saunders; 2015. 
  6. Batson OV. The role of the vertebral veins in metastatic processes. Ann Intern Med. 1942;16(1):38-45. 
  7. Batson OV. The function of the vertebral veins and their role in the spread of metastases. Ann Surg. 1940;112(1):138-149. 

 

Suggested Reading

Reinhard KR, Miller ME, Evans HE. The craniovertebral veins and sinuses of the dog. Am J Anat. 1962;111:67-87.

Authors

Laura O'Sullivan

VMD Media Veterinary Hospital, Media, Pennsylvania

Laura O’Sullivan, VMD, is a general practitioner at Media Veterinary Hospital in Media, Pennsylvania. Dr. O’Sullivan earned her undergraduate degree from Villanova University. Before her career in general practice, she completed a rotating internship at Red Bank Veterinary Hospital followed by a neurology and neurosurgery internship at Massachusetts Veterinary Referral Hospital.

Eric N. Glass

MS, DVM, DACVIM (Neurology) Red Bank Veterinary Hospital/Compassion First Pet Hospital

Eric N. Glass, MS, DVM, DACVIM (Neurology), is section head of neurology and neurosurgery at Red Bank Veterinary Hospital/Compassion First Pet Hospital in Tinton Falls, New Jersey. Dr. Glass received his DVM from Cornell University. He completed a rotating internship at The Animal Medical Center in New York City and a residency in neurology and neurosurgery at University of Pennsylvania. His clinical interests include neurosurgery and correlating neurologic signs with the neuroanatomic diagnosis. 

Gena Silver

MS, DVM, DACVIM (Neurology) Massachusetts Veterinary Referral Hospital, Woburn, Massachusetts

Gena Silver, MS, DVM, DACVIM (Neurology), earned her DVM from Atlantic Veterinary College in Prince Edward Island, Canada. She then completed a small animal medicine and surgery internship and a 3-year residency in neurology and neurosurgery at Washington State University, where she remained on faculty for one year as a clinical instructor of neurology and neurosurgery. She is a member of the American College of Veterinary Internal Medicine, American Veterinary Medical Association, and Massachusetts Veterinary Medical Association and is an active board member of the Veterinary Association of the North Shore. Her special interest is in disk diseases.

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