Nonsteroidal antiinflammatory drugs (NSAIDs) are commonly prescribed for controlling pain in cats with acute and chronic conditions through inhibition of prostaglandin synthesis. Two isoforms of cyclooxygenase mediate the formation of the prostanoids cyclooxygenase-1 (COX-1) and cyclooxygenase 2 (COX-2). In the feline kidney, prostaglandins have a variety of effects and are important in renal function by their participation in the renin-angiotensin-aldosterone system by promoting the release of renin from the kidney in response to extracellular fluid volume depletion. Both COX-1 and COX-2 are expressed in the canine kidney, but it is unknown if this is the case in the feline kidney. We do know that feline chronic kidney disease is a prostaglandin 2-dependent state. Since NSAIDs reduce glomerular filtration rate, they should be administered with caution and only to well-hydrated animals, which should be monitored by measuring serum creatinine and doing urinalysis 5 days after NSAID therapy is started.

COMMENTARY: This paper concisely and clearly describes the fundamental role of prostaglandins and prostaglandin inhibitors in general; then delves further into the specific use of NSAIDs in cats. The conclusions are supported by up-to-date information on current understanding of the physiology and pharmacology of NSAIDs in this species. -- David F. Senior, BVSc, Diplomate ACVIM & ECVIM-CA

What we need to know about NSAIDs and cat kidneys. Brown SA. Proc NAVC 2008, p 733.

• Metaflumizone is a novel insecticide that blocks sodium channels.
• There were no adverse reactions in cats even at 5 times the recommended dose.
• Repeated use of metaflumizone caused no adverse health effects.