Ingestion of NSAIDs (both human and veterinary formulations) is common in dogs. Vomiting, GI ulceration, and acute kidney injury (AKI) are expected with overdose due to reduced synthesis of protective prostaglandins.
This study aimed to evaluate clinical signs and identify prognostic factors in 125 dogs with NSAID overdose presented to an emergency clinic over an 11-year period. Ibuprofen, carprofen, naproxen, and deracoxib were most commonly ingested, and most exposures (96%) were a single acute ingestion.
Clinical signs included vomiting (36.8%), anorexia (15.2%), diarrhea (10.4%), hematemesis (8%), and melena (7.2%). ALT and ALP were elevated in >33% of dogs, possibly because of NSAID overdose, a pre-existing condition, or reactive hepatopathy secondary to gastroenteritis.
Most dogs (96%) survived to discharge. Nine dogs were discharged with incomplete renal recovery, 7 of which had follow-up data available. Six of the 7 dogs regained renal function within one year.
Duration of anorexia, when confounded for age, was a prognostic factor for death or euthanasia prior to discharge. There was no relationship between age, sex, or neuter status and outcome.