Content continues after advertisement

microRNA May Help Distinguish GI Cancer from Chronic Inflammatory Enteropathy

Clinical Pathology

|January 2023

Sign in to Print/View PDF

Accurate and timely diagnosis of GI cancer is important for prognosticating, initiating appropriate treatment, and improving outcomes; however, differentiating GI cancer from chronic inflammatory enteropathy can be difficult due to overlapping, nonspecific clinical signs (eg, vomiting, diarrhea, weight loss). Ultrasound findings are often equivocal, and other diagnostics (eg, endoscopic and surgical biopsy) can be costly and invasive and may require anesthesia. 

This prospective, case-controlled study used small RNA sequencing to screen for fecal and serum microRNAs (miRNAs) in 6 dogs with GI cancer, 9 dogs with chronic inflammatory enteropathy, and 6 healthy dogs. Additional dogs were recruited for biomarker identification. Total participants included 24 dogs with GI cancer, 10 dogs with chronic inflammatory enteropathy, and 10 healthy dogs. 

Reverse transcription quantitative real-time PCR was used to establish fecal and serum miRNA panels that may distinguish between GI cancer and chronic inflammatory enteropathy. Results revealed 3 fecal miRNAs and 3 serum miRNAs that may facilitate early differentiation before more invasive diagnostics are pursued. Larger studies including dogs with more diverse chronic GI disease are needed to validate these findings.


For global readers, a calculator to convert laboratory values, dosages, and other measurements to SI units can be found here.

All Clinician's Brief content is reviewed for accuracy at the time of publication. Previously published content may not reflect recent developments in research and practice.

Material from Clinician's Brief may not be reproduced, distributed, or used in whole or in part without prior permission of Educational Concepts, LLC. For questions or inquiries please contact us.


Clinician's Brief:
The Podcast
Listen as host Alyssa Watson, DVM, talks with the authors of your favorite Clinician’s Brief articles. Dig deeper and explore the conversations behind the content here.
Clinician's Brief provides relevant diagnostic and treatment information for small animal practitioners. It has been ranked the #1 most essential publication by small animal veterinarians for 9 years.*

*2007-2017 PERQ and Essential Media Studies

© 2023 Educational Concepts, L.L.C. dba Brief Media ™ All Rights Reserved. Terms & Conditions | DMCA Copyright | Privacy Policy | Acceptable Use Policy