Balanced anesthesia (ie, combining different drug classes and regional anesthesia techniques) may reduce hypotension and hypercarbia from excessive anesthetic drugs and provide additional perioperative analgesia. Forty-two dogs were divided into 2 groups: group L received intratesticular lidocaine injections 5 minutes before surgical castration, and group S received an equal volume of saline. There were no significant differences in baseline heart rate (HR), mean arterial pressure (MAP), or respiratory rate (RR). Dogs in group L had lower maximum values for HR and MAP compared with dogs in group S and smaller increases in HR during exteriorization of the first testis. Differences in MAP existed during all surgical events and time points, with less change in MAP for group L during skin excision, exteriorization of the first testis, and clamping of both spermatic cords. Although there was no significant difference in magnitude of increase of intraoperative RR, group S reached its highest RR earlier than group L. There were no significant differences in requiring additional propofol or rescue analgesia. Lidocaine effects likely wore off before completing surgery, explaining why there were no significant differences in HR and RR during second testis removal or in the magnitude of intraoperative RR or requirement for rescue analgesia. However, intratesticular lidocaine did provide decreased response to noxious stimuli based on HR, RR, and MAP.