Feline plasma cell pododermatitis (FPP) most commonly causes swelling of the metacarpal pads, metatarsal pads, or digital pads. These signs are followed by hyperkeratosis and ulcerations that may bleed. The majority of cases are diagnosed late in the disease process.
The cause of FPP is unknown, but immune hyperreactivity is suspected based on positive response to immunomodulatory therapy.1,2 Food hypersensitivity has been associated with FPP in some patients, and improvement may be noted with diet trials.*
Seasonal waxing and waning—particularly in spring and summer—have been described, but current studies have not identified an infectious causative agent.3
Related Article: Pododermatitis
One study noted that more than half of cats with FPP were FIV-positive; however, viral and/or retroviral association is often not seen.2 There is no reported sex, breed, or age predilection. Presentation varies from a single affected footpad to multiple affected pads on multiple paws. Footpads may be painful, and peripheral lymphadenopathy may be present.
Plasmacytic stomatitis, immune-mediated glomerulonephritis, and renal amyloidosis have been concurrently reported in rare cases.1