The Eastern diamondback rattlesnake, indigenous to the Southeastern U.S., belongs to the pit viper group and plays an important role in rodent control. Its potent venom has vasotoxic, hematoxic, cardiotoxic, neurotoxic, and necrogenic properties. A rattlesnake will attack to defend itself, which can result in life-threatening wounds. When on the losing end of such encounters, cats are commonly envenomated on the lateral body wall. Dogs tend to present a head-first posture. Life-threatening consequences include hypovolemia and fibrinogenolysis. Standard treatment of