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Differential Diagnosis: Eosinophilia

Julie Allen, BVMS, MS, MRCVS, DACVIM (SAIM), DACVP, Cornell University

Internal Medicine

|September 2019|Peer Reviewed

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Differential Diagnosis: Eosinophilia

Following are differential diagnoses, listed in order of likelihood, for patients presented with eosinophilia.

  • Parasitic diseases
    • Ectoparasites (eg, Ctenocephalides felis, Sarcoptes scabiei)
    • Endoparasites (eg, Dirofilaria immitis, Aelurostrongylus abstrusus, Cuterebra spp, Toxoplasma gondii, ascarids)
  • Allergic or hypersensitivity diseases
    • Flea allergy dermatitis
    • Atopy
    • Asthma
    • Food allergy
  • Hypoadrenocorticism
  • Eosinophilic bronchopneumopathy (Siberian huskies, Alaskan malamutes)
  • Eosinophilic granuloma complex
  • Eosinophilic enteritis
    • Feline GI eosinophilic sclerosing fibroplasia
  • Hypereosinophilic syndrome (rottweilers)
  • Paraneoplastic syndromes
    • Mast cell tumor
    • Lymphoma (primarily T-cell but can also be seen rarely with B-cell)
    • Squamous cell carcinoma
    • Thymoma
    • Others (eg, leiomyosarcoma, mammary carcinoma, urothelial carcinoma)
  • Eosinophilic meningoencephalitis of unknown etiology
  • Fungal infections (eg, Cryptococcus spp)
  • Drugs
    • Methimazole/carbimazole
  • Chronic eosinophilic leukemia


For global readers, a calculator to convert laboratory values, dosages, and other measurements to SI units can be found here.

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