Obesity remains the most common nutritional health problem in dogs. Adipose tissue was long considered metabolically inert, and its primary role in disease was attributed to stress on the joints and increased workload on the heart. However, the understanding of how obesity contributes to health problems has recently grown. Adipose tissue is now known to be metabolically active and is a major endocrine organ in the body. In addition to secreting hormones, adipose tissue produces protein signals and factors called adipokines, and many adipokines are linked to inflammation and the inflammatory response.1-5 Thus, obesity is considered a chronic inflammatory disease, and many obesity-related risks can be attributed to this inflammatory state.