Source
Ikai M, Murakami M, Kanei T, et al. Phosphorylation of Janus kinase 1 and signal transducer and activator of transcription 3 and 6 in keratinocytes of canine atopic dermatitis. Vet Dermatol. 2023. doi:10.1111/vde.13156
Research Note
Canine atopic dermatitis (CAD) is associated with hypersensitivity to environmental allergens mediated by immunoglobulin E, which is produced by plasma cells activated by type 2 helper T cytokines. Keratinocytes in humans are activated by type 2 helper T cytokines via the Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway, in which receptor binding by cytokines (eg, interleukin-4, interleukin-13) results in phosphorylation of JAKs and STATs.
This study investigated keratinocyte activation in the context of JAK1/STATs in CAD. The percentage of phosphorylated JAK1-positive keratinocytes was higher in primary CAD lesions than in healthy skin, and the percentage of phosphorylated STAT6-positive keratinocytes was higher in primary and secondary CAD lesions than in healthy skin, suggesting JAK1 and STAT6 may be potential therapeutic targets for CAD.
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