Blood transfusions have been used in ferrets to treat multiple causes of anemia. Using fresh donor blood within 4 hours poses little clinical risk, even without cross-matching of blood groups; however, blood banking is not routine for ferrets. This study aimed to determine the stability of ferret blood stored at 4°C in an anticoagulant citrate–phosphate–dextrose solution with adenine (CPDA).
Blood samples were taken from 2 male donors once a month for 5 months and stored for 4 weeks in polyethylene terephthalate (PET) blood tubes at a ratio of 6 mL blood:1 mL CPDA. Glucose, pH, lactate, potassium, and sodium were measured in samples at days 0, 7, 14, 21, and 28. Hematocrit measurement and microscopic blood smear examinations were also performed.
Evidence of RBC deterioration was observed more rapidly in the ferret samples than in that previously described for canine or human samples, with significant biochemical and morphological changes by day 7 and hemolysis evident by day 21. Although further studies are needed, these results indicate that ferret blood stored in CPDA should not be transfused after 7 days.
