Content continues after advertisement

Bisphenol A (BPA) in the Serum of Pet Dogs Fed Canned Dog Food

Tony Buffington, DVM, PhD, DACVN (Emeritus), University of California, Davis

Nutrition

|May 2017

Sign in to Print/View PDF

In the Literature

Koestel ZL, Backus RC, Tsuruta K, et al. Bisphenol A (BPA) in the serum of pet dogs following short-term consumption of canned dog food and potential health consequences of exposure to BPA. Sci Total Environ. 2017;579:1804-1814.


From the Page …

Bisphenol A (BPA) is a monomer (C15H16O2) used in the manufacture of some consumer products and food containers,1,2 including the lining of pet food cans.3 Structural similarities between BPA and estrogen permit BPA to bind to estrogen receptors in animal tissues, which has led to classification of BPA as an environmental endocrine disruptor.4

Experts disagree about the risks of BPA to human and animal health,5 with opinions ranging from “safe at current levels occurring in foods” (FDA) to “reliably produces effects in animals ... and many should be considered adverse.”6 Controversy also surrounds appropriate tissues to sample (eg, urine, serum)7; analytical approaches to avoid sample contamination during collection, transport, storage, and analysis8; and even reference ranges (which can range from pico- to nanomolar).9,10

This article’s authors sought to determine BPA content of 2 dog foods (one labeled “BPA-free”); serum concentrations of BPA in 14 healthy, privately owned, neutered adult dogs fed the foods for 2 weeks (food intake was not measured); and potential changes in a range of laboratory parameters. They found that although the diets differed in ingredient and nutrient composition, both contained BPA. Consequently, significant increases between food-deprived (pre-) and fed (post-) serum BPA concentrations were found in all dogs. These increases were associated with some serum chemistry (none outside reference ranges for the dogs studied) and microbiome changes. However, because of the presumed differences in diet composition (composition was not actually reported), it cannot be determined if the changes were due to changes in BPA intake or to compositional differences in the diets themselves. 

Given the study’s short duration and design (eg, small sample size, neutered adult animals), no conclusions about any effects of BPA on dogs can be drawn. Because of the presence of BPA in the product labeled “BPA-free,” however, continued skepticism about manufacturer marketing claims seems warranted.


… To Your Patients

Key pearls to put into practice:

1


Many aspects of BPA biology are controversial. A useful fact sheet can be found here.

2

The experimental design of this study precluded drawing actionable conclusions about effects of any amount of BPA in canned dog food on the dogs studied, let alone the larger populations of owned dogs.

3

A product labeled “BPA-free” had as much BPA as one with no BPA claim. Therefore, caution should be used when interpreting manufacturer marketing claims.

References

For global readers, a calculator to convert laboratory values, dosages, and other measurements to SI units can be found here.

All Clinician's Brief content is reviewed for accuracy at the time of publication. Previously published content may not reflect recent developments in research and practice.

Material from Clinician's Brief may not be reproduced, distributed, or used in whole or in part without prior permission of Educational Concepts, LLC. For questions or inquiries please contact us.

Podcasts

Clinician's Brief:
The Podcast
Listen as host Alyssa Watson, DVM, talks with the authors of your favorite Clinician’s Brief articles. Dig deeper and explore the conversations behind the content here.
Clinician's Brief provides relevant diagnostic and treatment information for small animal practitioners. It has been ranked the #1 most essential publication by small animal veterinarians for 9 years.*

*2007-2017 PERQ and Essential Media Studies

© 2023 Educational Concepts, L.L.C. dba Brief Media ™ All Rights Reserved. Terms & Conditions | DMCA Copyright | Privacy Policy | Acceptable Use Policy