Content continues after advertisement

Suspected Cutaneous Drug Reaction

Suspected Cutaneous Drug Reaction

Alison Diesel, DVM, DACVD, Texas A&M University

Dermatology

|March 2016|Peer Reviewed

Sign in to Print/View PDF

In veterinary patients, the symptoms of cutaneous drug reactions can be highly variable. Follow this management tree to promptly  identify and treat reactions when they occur. 

Author Insight

Adverse drug reactions can be highly variable:

  • May be idiosyncratic or dose dependent
  • May occur at any time during treatment, even if patient has tolerated the medication in the past
  • Clinical appearance from one animal to another can be highly variable. 

Although several classes of medication (eg, antibiotics, NSAIDs, parasiticides) have been reported to commonly cause adverse drug reactions, any medication (including supplements) has the potential to do so.1

Although this algorithm focuses primarily on suspected cutaneous drug reactions, it is important to remember that other body systems may also be affected.

  • Medications with known dose-dependent toxicities can target specific organs (eg, nephrotoxicity with aminoglycoside antibiotics, cardiotoxicity with doxorubicin administration).
    • However, with idiosyncratic reactions, clinical signs can be highly variable and may include cutaneous reactions, hematologic abnormalities or blood dyscrasia, or hepatic toxicity.1
  • Additional diagnostic tests may be indicated when clinical signs other than skin lesions are observed.
    • CBC, serum biochemistry profiles, and urinalyses are recommended in most cases.
    • Additional supportive care may be necessary based on clinical abnormalities identified (eg, blood products for hemolytic anemia, administration of hepatoprotectants for hepatotoxicity).

References and Author Information

For global readers, a calculator to convert laboratory values, dosages, and other measurements to SI units can be found here.

All Clinician's Brief content is reviewed for accuracy at the time of publication. Previously published content may not reflect recent developments in research and practice.

Material from Clinician's Brief may not be reproduced, distributed, or used in whole or in part without prior permission of Educational Concepts, LLC. For questions or inquiries please contact us.

Podcasts

Clinician's Brief:
The Podcast
Listen as host Alyssa Watson, DVM, talks with the authors of your favorite Clinician’s Brief articles. Dig deeper and explore the conversations behind the content here.
Clinician's Brief provides relevant diagnostic and treatment information for small animal practitioners. It has been ranked the #1 most essential publication by small animal veterinarians for 9 years.*

*2007-2017 PERQ and Essential Media Studies

© 2023 Educational Concepts, L.L.C. dba Brief Media ™ All Rights Reserved. Terms & Conditions | DMCA Copyright | Privacy Policy | Acceptable Use Policy