Red Light, Green Light: Phenylpropanolamine Extended-Release Tablets

Sponsored by PRN® Pharmacal

Although urinary incontinence can affect dogs of any age, sex, or breed, it is most common in spayed females.¹ The estimated prevalence of incontinence varies, depending on study design, but it is estimated to affect ≤20% of spayed female dogs.¹ Most of these patients are affected with urethral sphincter mechanism incontinence (USMI),¹ which is often, though not always, associated with alternations in sex hormones following gonadectomy.¹

According to the ACVIM 2024 consensus statement on canine urinary incontinence, alpha agonists (eg, phenylpropanolamine [PPA]) and estrogen compounds (eg, diethylstilbestrol, estriol)¹ are the recommended first-line treatment options for female dogs with USMI.¹ However, 8 out of 8 ACVIM panelists stated that they select PPA as their initial treatment for dogs with USMI.¹

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