Changing the kinetics of toxic substances can decrease their deleterious effects on patients.¹ Decontamination (ie, the process of reducing absorption or increasing excretion) can be achieved through emesis and therapeutic plasma exchange or administration of substances (eg, activated charcoal, cholestyramine, lipid emulsions) that bind toxins. Decontamination can be used to manage xylitol, bromethalin, phenobarbital, Vitamin D₃ (cholecalciferol), and ibuprofen toxicoses.