Source
Antończyk A, Ligocka-Kowalczyk Z, Ochota M. Choosing wisely: effects of propofol and alfaxalone induction on maternal and neonatal outcomes in isoflurane-anesthetized dogs undergoing cesarean section. Vet J. 2026;317:106618. doi:10.1016/j.tvjl.2026.106618
Research Note
Maternal stability and neonatal outcomes are important considerations when choosing an anesthetic protocol for Cesarean section. Propofol and alfaxalone are induction agents that cross the placenta; however, cardiorespiratory parameters are more stable with alfaxalone.
This study compared the effects of propofol or alfaxalone induction (followed by isoflurane maintenance) during Cesarean section on maternal hemodynamics, anesthetic requirements, neonatal vitality, and umbilical cord blood parameters.
Dogs undergoing elective Cesarean section (n = 35) were randomly assigned to receive either propofol and isoflurane (n = 17) or alfaxalone and isoflurane (ALFA; n = 18). Maternal cardiorespiratory parameters were monitored throughout the procedure; blood gas parameters and electrolytes were measured from umbilical blood vessel samples after birth. Adapted Apgar scores were assigned to neonates at 0, 5, and 20 minutes, and a full examination was performed at 90 minutes postdelivery.
Although both protocols were found to provide stable anesthesia, in the ALFA group, hypotension episodes occurred more frequently in dams after fetal removal and at surgical closure, and isoflurane requirements were higher. Neonates from dams in the ALFA group had higher umbilical cord pH (indicating reduced neonatal acidosis), lower partial pressure of carbon dioxide, and significantly higher 20-minute Apgar scores.
The authors concluded that alfaxalone for Cesarean section may offer more favorable outcomes for neonates; however, close intraoperative monitoring of maternal blood pressure is essential.
You are reading Research Notes, a research summary resource presented by Clinician's Brief. Clinician's Brief does not conduct primary research.