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In this episode, host Alyssa Watson, DVM, sits down with fellow general practitioner and Instinct team member Katie Moynihan, DVM, to walk through 4 recent studies on repurposed drugs: oclacitinib in cats, oral bezafibrate for canine hypertriglyceridemia, fosmidomycin for bacterial otitis externa in dogs, and intranasal levetiracetam for emergency seizure management in dogs. Together they dig into what the data actually supports, where the open questions remain, and which of these four uses is most actionable today.
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Key Takeaways
The oclacitinib study strengthens evidence that the drug is generally well-tolerated in cats, but it remains extra-label, lacks prospective controlled data, and requires higher doses than in dogs.
The bezafibrate study strengthens the case for bezafibrate as a safe and effective long-term adjunct for canine hypertriglyceridemia refractory to dietary management. However, bezafibrate is not commercially available in the United States.
Fosmidomycin is a mechanistically novel, stewardship-oriented topical otic agent that performed comparably to enrofloxacin in a well-designed but small study. It has One Health appeal due to targeting a pathway absent in human-adapted staphylococci, but it is not commercially available.
In the levetiracetam study, a compounded, concentrated solution administered intranasally rapidly reached the minimum therapeutic threshold in healthy dogs and maintained it for several hours. However, intranasal levetiracetam has not been tested in actively seizing dogs, requires a high-concentration compounded product, and has weaker evidence than intranasal benzodiazepines.
Resources:
https://www.cliniciansbrief.com/article/oclacitinib-skin-condition-treatment-cats
https://www.cliniciansbrief.com/article/treatment-bezafibrate-canine-hypertriglyceridemia
https://www.cliniciansbrief.com/article/intranasal-levetiracetam-seizure-dogs#-the-takeaways
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The Team:
Alyssa Watson, DVM - Host
Alexis Ussery - Producer & Multimedia Specialist